LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma
نویسندگان
چکیده
Attiyeh EF, et al. Identification of ALK as a major familial neuroblastoma predisposition gene. Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nakagawara A. Functional characterization of a new p53 mutant generated by homozygous deletion in a neuroblas-toma cell line. of C-terminal deleted p53 isoforms in neuroblastoma. et al. NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.
منابع مشابه
Correction: LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma
LGR5 is a marker of normal and cancer stem cells in various tissues where it functions as a receptor for R-spondins and increases canonical Wnt signalling amplitude. Here we report that LGR5 is also highly expressed in a subset of high grade neuroblastomas. Neuroblastoma is a clinically heterogenous paediatric cancer comprising a high proportion of poor prognosis cases (~40%) which are frequent...
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